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Molecular Epidemiology

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Molecular Epidemiology

Head of the Division: Dr. Philip Raj Abraham, Scientist - B

Unit of Molecular Epidemiology (UnMolE) is a new initiative of ICMR-VCRC to undertake studies on molecular epidemiological aspects of vector borne diseases.

Objectives

 Development of molecular tools/Biosensor for detecting filarial infection in vectors

 Development of Dengue NS1 antigen based kits for detection of dengue virus in Ae. aegypti and Ae. albopictus vectors

 Investigation of underlying mechanism of Insecticide resistance in vectors

 Development of xenomonitoring protocol as a surveillance & evaluation tool for major vector borne diseases such as,

  • Bancroftian Filariasis
  • Brugian Filariasis
  • Dengue
  • Malaria
  • Japanese encephalitis

Research Areas

Molecular epidemiology and molecular entomology of vector borne diseases, molecular mechanism of insecticide resistance on vectors and molecular xenomonitoring of vectors of public health importance

Staff List
Sr. No.Name of the staffDesignation
1Dr. Philip Raj Abraham HOD & Scientist - B
2Mr. R. BalasubramaniyanTechnical Officer - C
3Mr. S. MuthukumaravelTechnical Officer - C
4Mr. C. Saravanan       Technical Officer - C
5Mrs. M. Shabura         Technician-2
6Mr. P. Shanthakumar Technician-2
Ongoing Projects

Ongoing Projects

  • Exploring potential application of Dengue NS1 antigen kits for detection of Dengue virus in Aedes mosquito samples (IM-1903)

  • Filarial infection among ineligible population of MDA in an endemic area: Implications for elimination program (IM-2011)

  • Exploring potential application of plant lectins for detection of Dengue NS1 antigen (IM-2113)

  • Development of Monitoring and Evaluation protocol for accelerated MDA with IDA for Lymphatic Filariasis elimination programme (EM-1916)

  • Isolation, Evaluation and characterization of pesticide bio-degradation efficacy of mosquitocidal bacterial isolates for biocontrol and bioremediation. (IM – 2110)

  • Molecular characterization of Delta and Epsilon class of glutathione-S-transferases (GSTs) and cytochrome oxidase (P450s), which confer synthetic pyrethroids resistance in malaria vectors from Odisha State. (IM - 2111)

  • Molecular xenomonitoring of W. bancrofti infection in Culex quinquefaciatus vector mosquitoes in migrated population area (IM – 2112)

New Activities
  • New Activities

    • Development and evaluation of Recombinase Polymerase Assay for Detection of Wuchereria bancrofti in Man and Mosquitoes in a Lymphatic Filariasis Endemic Area

    • Development and evaluation of Aptamer based assay for detection of Wuchereria bancrofti larvae (L3 stage) in Culex quinquefasciatus

    • Filarial infection among out-migrants: Reaching the outreached during mass drug administration for elimination of lymphatic filariasis from an endemic area

    • Genome wide scanning of Wuchereria bancrofti populations in India: elucidating molecular ecology and the genetic impact of Mass Drug Administration

Infra structure – Laboratories
  • Infra structure – Laboratories

    • Genetic Analyzer (Applied Biosystems 3130XL)

    • Real Time PCR (Bio-Rad CFX 96)

    • Gradient PCR (Bio-Rad T100)

    • RNA Extractor (Thermo Scientific)

    • -86°C Deep freezer (Eppendorf)

    • -30°C Bio medical freezer (Sanyo)

    • Tissue lyser II (Qiagen)

    • Dry bath (Labnet)

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