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Innovation & Product Development

HomeResearch DivisionsInnovation & Product Development
HomeResearch DivisionsInnovation & Product Development
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Innovation & Product Development

Head of the Division: Dr. Nisha Mathew, Scientist-F

The thrust areas of research of this department include development of vector and parasite control agents, newer insecticide formulations and developing analytical methods for drugs and insecticides.

Two approaches have been made for the development of antifilarials - a search in the natural product combinatorial chemistry and the target structure based drug development. Isolated two macrofilaricidal lead molecules by bioassay guided fractionation from two medicinal plants Trachyspermumammi and Plumbago rosea.

Based on filarial GST as target structure for drug development, 11 macrofilaricidal napthoquinone analogues have been identified. Significant contributions have been made in the field of developing vector control agents such as mosquito repellents (DEPA, Essential oil combinations from plants), small molecules mosquito attractant blends, mosquito oviposition attractant (E-57), Insect growth regulator (DPE-28 and its controlled release formulation), Synthetic pyrethroid esters P-29 & P-38 for adulticidal and larvicidal activity.

Developed analytical methods for the analysis of Diethylcarbamazine (DEC) an antifilarial drug in medicated salt samples used in mass chemotherapy of filariasis using HPLC which is currently used as the gold standard and for cyclosporine A in fermentation samples.

To formulate and implement insecticides resistance management strategies in time, regular monitoring of vector susceptibility/ resistance to the insecticides under use is essential. For this standardised the methodology for making indigenous insecticide impregnated papers.

This department has produced four PhDs, one ICMR-PDF and 17 MSc dissertations.

Research Areas

Development of vector borne disease control agents/tools targeting the vector and the parasite

Staff List
Sr. No.Name of the staffDesignation
1Dr. Nisha MathewHOD & Scientist-F
2Mrs. R. AnilakumariTechnical Officer-C
3Mrs. Smruthidhara DasTechnical Officer
4Mr. M. SundharesanTechnical Assistant
5Mrs. D.KavyasreePhD Scholar
Ongoing Projects

Ongoing Projects

  • Drug delivery targeting Lymphatic system: a novel nanomedicine - based approach to fight lymphatic filariasis (LF). ICMR-funded.
  • Development of Nano-formulations of repurposed drugs and in vitro and in vivo testing for antifilarial activity.
  • Development of an eco-friendly mosquito larvicide for dengue/chikungunya vector control.
  • Setting up facility at ICMR-VCRC for production of insecticide impregnated papers (IIPs) for resistance monitoring.
  • Nisha Mathew, Kalyanasundaram M & Balaraman K. Novel macrofilaricidal composition and process for preparing the same. Indian PatentNo.280638 (2017).
  • Nisha Mathew, Kalyanasundaram M & Balaraman K. Macrofilaricidal activity of monoterpene derivatives having phenolic characteristics from the fruit extract of Trachyspermumammi against filariasis. Indian PatentNo.274393(2016).
  • Nisha Mathew& M. Kalyanasundaram. A technology for the production of controlled release formulation of an insect growth regulator for mosquito larval control. Indian Patent. No. 191820 (2005).
  • K. Balaraman & Nisha Mathew. Process for the preparation of Cyclosporin-A from Tolypocladium species.
  • US patent No. 5, 656, 459 (1997);
    Brazilian PatentBR9601017 (1997);
    European Patent EP-96-356060/36(1996);
    Indian patent No. 183940 (2000);
    DE69521193T (2001);
    Canadian Patent CA-2142240 C (2002).
Significant research findings/contributions
  • Preparation and supply of insecticide impregnated papers (IIPs) to National Vector Borne Disease Control Programme (NVBDCP) for monitoring susceptibility/resistance in vector mosquitoes in the country. ICMR-VBDSF Fund.
  • Development of naphthoquinone analogues as macrofilaricidal agents. ICMR Translational Research Fund.
  • Development of monoterpenes extracted from the seeds of Trachyspermumammias macrofilaricidal composition. ICMR Translational Research Fund.
  • In vivo screening of six promising 1‐N‐methyl‐4‐(substituted) benzoyl/phenyl acetyl piperazides for macrofilaricidal activity against Brugia malayi in animal models.Funded by Department of Science & technology (DST), Govt. of India.
  • Filarial Glutathione S-transferase as a possible biochemical target for macrofilaricidal drug development- synthesis and evaluation of substituted 1,4-naphthoquinones. Funded by Department of Science & technology (DST), Govt. Of India.
  • Studies on the antifilarial potential of Ayush SL formulations (Funded by Centre for Research in Ayurveda & Siddha (CCRAS), Govt. of India.
  • Development of antifilarial agents of plant origin (Funded by International Foundation for Science (IFS), Sweden.
  • Synthesis of 1-methyl-4-substituted benzoyl piperazines for the development of a macrofilaricide. (Funded by Department of Science & technology (DST), Govt. Of India.
  • Development of Controlled release formulations of Baytex, a mosquito larvicide and Starycide, an IGR. (Funded by M/s Bayers India Ltd., Mumbai).
  • Development of an effective formulation for DPE-28 (Indian Pat. No. 191820), an insect growth regulator developed at VCRC for use in the field conditions for Culex quinquefasciatus control.
  • Development of new mosquito control agents based on anthranilic diamides targeting the insect ryanodine receptor.
  • Isolation and characterization of novel mosquitocidal compounds from natural products.
  • Synthesis and evaluation of mosquito attractants for vector surveillance and control.
  • Synthesis of structural analogues of the macrofilaricidal lead molecules P-19 & P-21.
  • Studies on the release kinetics of the controlled release formulation of DPE-28, an indigenous insect growth regulator for the mosquito larval control.
  • Synthesis and structure activity relationship studies in pyrethroids derived from 3-methyl-2-phenoxybutanoic acids against Cx. quinquefasciatus.
  • Synthesis and quantitative structure activity relationship studies in diphenyl ureas for IGR activity.
  • Studies on the development of liposphere lotion formulation of insect repellents.
  • Synthesis and evaluation of esters for mosquito oviposition attractancy.
  • Synthesis of diphenyl ethers for insect growth regulating activity.
  • Synthesis and evaluation of amides for mosquito repellent activity.
Infrastructure (Labs)

Mettler Toledo Compact Parallel synthesizer, Shimadzu-FTIR, Thermofinnigan-HPLC, Molecular Devices- Spectrophotometer, MPLC System, FPLC System (High performance flash chromatography), CO2 Incubator, Rotary vacuum evaporator, Bench top Ultra Centrifuge, Fume Hood, Catalytic hydrogenation apparatus, Melting point Apparatus, Electronic balance, Spray Drier, Freeze drier, Hot air oven, Magnetic stirrer.

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