Products Developed

Bio-Control Agents Against Mosquitoes

1. Bacillus thuringiensis var. israelensis
2. Pseudomonas fluorescens
3. Bacillus subtilis
4. B. thuringiensis tochigiensis var. israelensis
5. Fly-ash based mosquitocidal biopesticides
6. Biocidal composition and preparation there of
7. Romanomermis iyengari mosquito parasitic nematodes

By-Products of Bio-Pesticides

1. Thrombinase
2. L-DOPA
3. Dehairing enzyme
4. Anti-microbial secondary metabolite from Bacillus amyloliquefaciens
5. Cyclosporine

Diagnostics

1. Molecular diagnostics for Anopheles fuviatilis and An. Culicifacies
2. Molecular diagnostics for Sand flies
3. Immuno-diagnostic tool for antigen assay
4. New DNA extraction method
5. RT-PCR assay for detection of infective (L3) stage larvae of Wuchereria bancrofti
6. Electrochemical based biosensor for detection of Wuchereria bancrofti in vectors
7. DNA Barcodes for Mosquitoes
8. Detection of JE virus antigen in desiccated vector mosquitoes
9. The isolation methodology of JE virus from mosquito larvae and human by using Toxorhynchites splendens mosquitoes by immuno-fluorescence assay (Toxo- IFA system)
10. Methodology optimised for Dengue virus antigen detection in desiccated specimens of Aedes aegypti

Chemical Control Agents against Mosquitoes

1. DEPA-a synthetic mosquito repellent
2. DPE-28 an insect growth regulator (IGR) against Culex quiquefasciatus larvae
3. Synthetic pyrethroid esters P-38 & P-29 effective against Culex quiquefasciatus
4. Oviposition attractant, E-57 effective against Culex quiquefasciatus
5. Mosquito attractant blend of small molecules attracting host seeking Aedes aegypti mosquitoes
6. Blend of essential oils as mosquito repellent against Aedes aegypti

Parasite Control Agents/Analytical Methods

1. A macrofilaricidal lead molecule, a monoterpene with phenolic properties from Trachyspermum ammi, an indigenous medicinal plant.
2. Macrofilaricidal lead molecule 5-hydroxy-2-methyl-1,4-naphthoquinone from Plumbago rosea/indica an indigenous medicinal plant.
3. Modelled 3-D structures of filarial GST of Wuchereria bancrofti (PDB ID: 1SFM), Brugia malayi (PDB ID: 1SJO) and transforming growth factor tgh-2 of B.malayi (PDB ID: 1ZCG)
4. Optimization of HPLC conditions for the analysis of Cyclosporins A, B, & C in fermentation samples
5. HPLC method for analysis of Diethylcarbamazine in DEC-medicated salt

Tools for Decision Support

1. Mathematical models
2. Modelling the impact of MDA with 3-drug vs 2-drug regimen for LF elimination
3. Xenomonitoring, an alternative for human sampling in TAS
4. Risk Mapping and Modelling using GIS
5. Application of space technology for forecasting Japanese encephalitis (JE) vector abundance

Drug Trials against Lymphatic Filariasis

1. Mass drug administration (MDA) with annual single dose DEC (6 mg/kg body wt.) Kerala-1987, Puducherry-1988-1990
2. Safety, efficacy and effectiveness of DEC and Ivermectin alone and in combination against lymphatic filariasis 1993-2003
3. Feasibility of elimination of persistent foci of transmission by supplementing DEC fortified salt 2001-2008
4. Effectiveness of co-administration of DEC and Albendazole in comparison with DEC alone as Mass Drug administration towards filariasis elimination (2000-2006)
5. Community based trial in Yadgir, Karnataka to assess safety, acceptability and efficacy of adding a third drug, Ivermectin, to the existing regime of two drugs (2016–2017).

Site Specific Strategies for the Control of Vector Borne Diseases

1. Malaria in Thenpennaiyar riverine tract of Tamil Nadu (1977 – 1983)
2. Malaria in Salem urban area (1976 – 1979)
3. Malaria in Rameswaram island, Tamil Nadu (1981 –1985)
4. Malaria in tribal tract of Orissa (1986 – 1991)

Demonstration Projects

1. Malaria control in coastal ecosystem [1980 – 1985]
2. Control of Bancroftian filariasis through IVM strategy in urban areas of Pondicherry [1981 – 1986]
3. Malaria control in a tribal area involving the Traditional Health Healers [1995 – 2000]
4. Technology Mission Project for the Control of Brugian Filariasis in Shertallai, Kerala [1986 – 1997]
5. Development and demonstration of Integrated Vector management strategy for the control of dengue/chikungunya vectors in rubber plantations of Kerala [2008 – 2013]
6. School based vector control and surveillance for prevention of dengue in Puducherry [2013 – 2016]

Master Plans for Mosquito Control

1. Municipal Corporation, Bangalore, Karnataka [1980 – 1987]
2. Township, Neyveli Lignite Corporation, Tamil Nadu [1985 – 1989]
3. Municipal Corporation, Kochi, Kerala [1990 – 1996]
4. Municipal Corporation, Vishakhapatnam, AP [1999 – 2000]